Merial Introduces ZACTRAN® (Gamithromycin)

A new rapid response product for the treatment and control of Bovine Respiratory Disease (BRD)1

DULUTH, GA – July 14, 2011 –ZACTRAN® (gamithromycin), a new antimicrobial from Merial, provides producers with a rapid-response weapon in the battle against BRD.1 It can be used for control of BRD in high-risk cattle or as a first-pull treatment of sick cattle.2

“BRD causes between $800 to $900 million annually in economic losses from death, reduced feed efficiency and treatment costs.3 Given the significant impact of BRD, producers need cattle to respond quickly to treatment,” says Bruce Nosky, DVM, Manager, Merial’s Large Animal Veterinary Services. “In field studies, cattle treated with ZACTRAN showed a rapid improvement in BRD clinical signs.1 More than three-quarters of the cattle with a fever had a significant decrease in temperature within 24 hours.4 And the majority of those cattle treated with ZACTRAN remained healthy throughout the 10-day study.”1

Dr. Nosky adds that in additional field trials for BRD control, the majority of lightweight, long-haul and high-risk cattle that received ZACTRAN on arrival to control BRD showed significantly less disease during the 10-day study compared to non-treated calves.5

ZACTRAN is a prescription, ready-to-use solution for the treatment of BRD associated with Mannheimia haemolytica, Pasteurella multocida and Histophilus somniin beef and non-lactating dairy cattle, as well as the control of respiratory disease in beef and non-lactating dairy cattle at high risk of developing BRD associated with M.haemolytica and P. multocida.2

ZACTRAN is administered subcutaneously (SC) at a dose of 2 mL/110 lbs.2 The product is available in three ready-to-use sizes. The 100, 250 and 500 mL bottles contain sufficient solution to treat 10, 25 and 50 head of 550 lb. cattle, respectively.2 Every 250 and 500 mL bottle of ZACTRAN includes a durable bottle protector to reduce the risk of breakage during shipping and everyday use. The bottom of the bottle protector also includes a convenient chute-side hanger.

ZACTRAN is brought to you by Merial, the maker of IVOMEC® (ivermectin) Brand Products.

Producers can learn more about ZACTRAN by contacting their veterinarian or visiting

IMPORTANT SAFETY INFORMATION: For use in cattle only. Do not treat cattle within 35 days of slaughter. Because a discard time in milk has not been established, do not use in female dairy cattle 20 months of age or older, or in calves to be processed for veal. The effects of ZACTRAN on bovine reproductive performance, pregnancy and lactation have not been determined.

About Merial

Merial is a world-leading, innovation-driven animal health company, providing a comprehensive range of products to enhance the health, well-being and performance of a wide range of animals. Merial employs approximately 5,600 people and operates in more than 150 countries worldwide. Its 2010 sales were more than $2.6 billion. Merial is a Sanofi company. For more information, please see

®ZACTRAN and IVOMEC are registered trademarks of Merial Limited. ©2011 Merial Limited, Duluth, GA.

All rights reserved. RUMIOTD1132-B (05/11)

1 Sifferman RL, Wolff WA, Holste JE, et al. Field efficacy evaluation of gamithromycin for treatment of bovine respiratory disease in cattle at feedlots. Intern J Appl Res Vet Med. 2011;9(2):171-180.

2 ZACTRAN product label approved 2011.

3 Stotts D. Making BRD DOA as a cattle industry concern. Oklahoma State University pub 2010. Available at: Accessed April 8, 2011.

4 Data on file at Merial.

5 Lechtenberg K, Daniels CS, Royer GC, et al. Field efficacy study of gamithromycin for the control of bovine respiratory disease in cattle at high risk of developing the disease. Intern J Appl Res Vet Med. 2011;9(2):189-197.