Prevent prussic acid toxicity

Clinical signs of prussic acid toxicity include muscle tremors, increased respiration rate and excess salivation.

September 13, 2023

3 Min Read
OSU Agriculture/Todd Johnson

Prussic acid toxicity, commonly linked to the consumption of Johnsongrass, is a serious condition that can be fatal to livestock. Recent rains after a period of dry weather have heightened the toxicity risk.

Barry Whitworth, DVM, senior Extension specialist/state Beef Quality Assurance coordinator for the Oklahoma State University Department of Animal and Food Sciences, said when temperatures rise and the ground dries out, certain plants in the sorghum family become toxic and can kill cattle at a rapid rate. Johnsongrass is one of Oklahoma’s most invasive plants.

“Hydrocyanic acid, which is also referred to as cyanide or prussic acid, is a toxin created when the harmless hydrocyanic glycosides in plants are stressed or break down,” he said. “Once a plant’s hydrocyanic glycosides are damaged, they quickly convert to prussic acid.”

When cattle ingest plants high in hydrocyanic glycoside and break them down by chewing, prussic acid is released in the rumen and absorbed into the bloodstream. Whitworth explained that once prussic acid reaches the circulatory system, the toxin prevents cells in the body from taking up oxygen. The blood becomes saturated with oxygen that cannot be absorbed by cells, and cattle perish from asphyxiation within minutes. Rosslyn Biggs, DVM, OSU Extension beef cattle specialist, explains what happens in this video from SUNUP, the television show of OSU Agriculture.

Clinical signs of prussic acid toxicity are:

  • Muscle tremors

  • Increased respiration rate

  • Excess salivation

  • Staggering

  • Convulsions

  • Collapse

Producers should note prussic acid levels are highest in the leaves of young plants, and the upper leaves contain the most toxin. Stress from drought or frost increases prussic acid as well as fertilizing with large amounts of nitrogen and nitrogen/phosphorus soil imbalances.

While Johnsongrass is high in prussic acid, the nitrate toxicity of other sorghum plants such as Foxtail millet is low. Ranchers should first identify the toxicity level of any sorghum variety intended for grazing purposes. Forage samples can be submitted to any OSU Extension county office for testing at OSU’s Soil, Water and Forage Analytical Laboratory in Stillwater.

Once a sample of grass is collected, producers should immediately take it to the local Extension office for testing. Bay said a county Extension educator can also meet the rancher on-site and perform a test at the field. When moving cattle from one pasture to another along a road, she also advised to take caution with the Johnsongrass that often grows in roadside ditches.

Take the following steps to prevent prussic acid toxicity:

  • Never turn hungry cattle into a new pasture

  • Take soil samples and fertilize accordingly

  • Graze mature plants

  • Wait until plants are cured before grazing after frost (at least seven days)

  • Rotate pastures to keep cattle from consuming lush regrowth

  • Place one or two cows in a pasture and observe for problems before turning in all cattle

When an animal displays signs of prussic acid toxicity, the producer should immediately remove all animals that appear to be normal to a new pasture and contact their veterinarian. Sick animals can recover if treated quickly with sodium nitrite and sodium thiosulfate to reverse the toxicity.

Additional OSU Extension resources are available through SUNUP:

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